Cervical Cerclage: A Comprehensive Monograph on Indications, Techniques, Outcomes, and Evolving Evidence
Keywords:
Cervical Cerclage, Preterm birth, cervical insufficiencySynopsis
Cervical cerclage is a surgical intervention designed to reinforce cervical integrity and prevent preterm birth (PTB) in women at high risk of cervical insufficiency. Since its introduction in the 1950s, the procedure has evolved considerably in terms of patient selection criteria, operative technique, timing, and adjunct management strategies. This monograph provides a comprehensive, evidence-based review of cervical cerclage, encompassing its historical development, pathophysiological rationale, classification of indications (history-indicated, ultrasound-indicated, and physical examination-indicated), operative approaches (McDonald, Shirodkar, and abdominal cerclage), perioperative management, outcomes, complications, and controversies. Special attention is given to the role of cervical length screening, the place of cerclage relative to competing interventions such as vaginal progesterone and cervical pessary, and the management of cerclage in multiple gestations. The monograph synthesises current evidence from randomised controlled trials, systematic reviews, and major clinical guidelines to inform contemporary obstetric practice.
References
American College of Obstetricians and Gynecologists. (2022). Practice bulletin no. 142: Cerclage for the management of cervical insufficiency. Obstetrics & Gynecology, 140(5), e174–e194. https://doi.org/10.1097/AOG.0000000000004928
Benson, R. C., & Durfee, R. B. (1965). Transabdominal cervico uterine cerclage during pregnancy for the treatment of cervical incompetency. Obstetrics & Gynecology, 25(2), 145–155.
Berghella, V., Odibo, A. O., To, M. S., Rust, O. A., & Althuisius, S. M. (2005). Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth: A meta-analysis. Obstetrics & Gynecology, 106(1), 181–189. https://doi.org/10.1097/01.AOG.0000168435.87430.89
Berghella, V., Rafael, T. J., Szychowski, J. M., Rust, O. A., & Owen, J. (2011). Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth: A meta-analysis. Obstetrics & Gynecology, 117(3), 663–671. https://doi.org/10.1097/AOG.0b013e31820ca847
Carter, J. F., Soper, D. E., Pollock, M., & Van Dorsten, J. P. (2009). Abdominal cerclage for the treatment of recurrent cervical insufficiency: Laparoscopy or laparotomy? American Journal of Obstetrics and Gynecology, 201(1), 111.e1–111.e4. https://doi.org/10.1016/j.ajog.2009.02.011
Dawood, F., Bhide, A., & Bhide, P. (2007). Transabdominal cervicoisthmic cerclage. In The Cochrane Database of Systematic Reviews (Issue 2, Art. No. CD003355). https://doi.org/10.1002/14651858.CD003355.pub2
Feltovich, H. (2017). Cervical evaluation: From ancient medicine to precision medicine. Obstetrics & Gynecology, 130(1), 51–63. https://doi.org/10.1097/AOG.0000000000002100
Fonseca, E. B., Celik, E., Parra, M., Singh, M., & Nicolaides, K. H. (2007). Progesterone and the risk of preterm birth among women with a short cervix. New England Journal of Medicine, 357(5), 462–469. https://doi.org/10.1056/NEJMoa067815
Goya, M., Pratcorona, L., Merced, C., Rodo, C., Valle, L., Romero, A., Juan, M., Rodriguez, A., Muñoz, B., Santacruz, B., Bello-Muñoz, J. C., Llurba, E., Higueras, T., Cabero, L., & Carreras, E. (2012). Cervical pessary in pregnant women with a short cervix (PECEP): An open-label randomised controlled trial. The Lancet, 379(9828), 1800–1806. https://doi.org/10.1016/S0140-6736(12)60030-0
Harger, J. H. (1980). Comparison of success and morbidity in cervical cerclage procedures. Obstetrics & Gynecology, 56(5), 543–548.
Honest, H., Bachmann, L. M., Gupta, J. K., Kleijnen, J., & Khan, K. S. (2009). Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: Systematic review. BMJ, 325(7359), 301–304. https://doi.org/10.1136/bmj.325.7359.301
Kyser, K. L. (2012). The psychological impact of cervical incompetence and cerclage on pregnant women. Journal of Obstetric, Gynecologic & Neonatal Nursing, 41(6), 734–744. https://doi.org/10.1111/j.1552-6909.2012.01404.x
Kyrgiou, M., Athanasiou, A., Paraskevaidi, M., Mitra, A., Kalliala, I., Martin-Hirsch, P., Arbyn, M., Bennett, P., & Paraskevaidis, E. (2016). Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: Systematic review and meta-analysis. BMJ, 354, i3633. https://doi.org/10.1136/bmj.i3633
Liem, S. M. S., van Pampus, M. G., Mol, B. W. J., & Bekedam, D. J. (2013). Cervical pessaries for the prevention of preterm birth: A systematic review. Obstetrics & Gynecology International, 2013, Article 576723. https://doi.org/10.1155/2013/576723
McDonald, I. A. (1957). Suture of the cervix for inevitable miscarriage. Journal of Obstetrics and Gynaecology of the British Empire, 64(3), 346–350. https://doi.org/10.1111/j.1471-0528.1957.tb02650.x
Medical Research Council/Royal College of Obstetricians and Gynaecologists Working Party on Cervical Cerclage. (1993). Final report of the Medical Research Council/Royal College of Obstetricians and Gynaecologists multicentre randomised trial of cervical cerclage. British Journal of Obstetrics and Gynaecology, 100(6), 516–523. https://doi.org/10.1111/j.1471-0528.1993.tb15300.x
Nicolaides, K. H., Syngelaki, A., Poon, L. C., de Paco Matallana, C., Plasencia, W., Molina, F. S., Picciarelli, G., Tul, N., Celik, E., Llorente, M., & Landau, R. (2016). A randomized trial of a cervical pessary to prevent preterm singleton birth. New England Journal of Medicine, 374(11), 1044–1052. https://doi.org/10.1056/NEJMoa1511691
Norman, J. E., Marlow, N., Messow, C.-M., Shennan, A., Bennett, P. R., Thornton, S., Robson, S. C., McConnachie, A., Petrou, S., Gillespie, A., Brocklehurst, P., & Norrie, J. (2016). Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): A multicentre, randomised, double-blind trial. The Lancet, 387(10033), 2106–2116. https://doi.org/10.1016/S0140-6736(16)00350-0
Odibo, A. O., Berghella, V., To, M. S., Rust, O. A., Althuisius, S. M., & Iams, J. D. (2003). Shirodkar versus McDonald cerclage for the prevention of preterm birth in women with short cervical length. American Journal of Perinatology, 20(6), 325–329. https://doi.org/10.1055/s-2003-42693
Roman, A., Rochelson, B., Fox, N. S., Hoffman, M., Berghella, V., Rafael, T., Martinelli, P., Saccone, G., & Beckmann, M. (2015). Efficacy of ultrasound-indicated cerclage in twin pregnancies. American Journal of Obstetrics and Gynecology, 212(6), 788.e1–788.e6. https://doi.org/10.1016/j.ajog.2015.01.032
Romero, R., Dey, S. K., & Fisher, S. J. (2014). Preterm labor: One syndrome, many causes. Science, 345(6198), 760–765. https://doi.org/10.1126/science.1251816
Romero, R., Conde-Agudelo, A., El-Refaie, W., Rode, L., Brizot, M. L., Cetingoz, E., Serra, V., Da Fonseca, E., Abdelhafez, M. S., Tabor, A., Perales, A., Hassan, S. S., & Nicolaides, K. H. (2018). Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: An updated meta-analysis of individual patient data. Ultrasound in Obstetrics & Gynecology, 49(3), 303–314. https://doi.org/10.1002/uog.17397
Royal College of Obstetricians and Gynaecologists. (2011). Cervical cerclage (Green-top Guideline No. 60). RCOG Press.
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